Episodes: 2017

New York comedian Mike Brown is a big fan of objective cause-and-effect scenarios. This drew him into playing video games, studying math and engineering, and ultimately getting on stage to tell jokes and get laughs. The thing is, sometimes you have to face events that are completely senseless.

New York comic Janelle James never even imagined being a comedian. She had grown up in the Virgin Islands, worked in fashion PR, had two kids, and was living in Illinois when she first walked on stage at an open mic night. She was 30 years old. But as soon as she hit the stage, […]

She’s the author of bestselling books and an incredibly popular blog, but Jenny Lawson showed up to our interview wondering, at least a little, if her appearance on this show and her whole career, really, was part of some delusion. It’s not. She’s the real thing: an incredibly funny and honest writer with a legion […]

We’ve gathered up a whole lot of tips, tricks, ideas, and stories to help you get through this time of year when merriness and jolliness aren’t always in abundant supply. Hear holiday thoughts from Wil Wheaton, Margaret Cho, Jenny Lawson, John Green, Aimee Mann, and more. Plus, a story about a slobbering zebra.

You know those things that happened but that you don’t talk about very much? Or even at all? Because they’re too upsetting? In this episode, host John Moe and guest Ana Marie Cox put those things on the table. Ana is a journalist, pundit, and podcaster; she talks about the lowest point in her mental […]

Growing up, actor and writer Julie Klausner was too busy battling depression and daydreaming about an imagined Merlot-sipping cosmopolitan adulthood to really engage in the world itself. It wasn’t until she entered the world of comedy and improv as an adult that things really started to click into place. That led to creating Difficult People, […]

Long before Jeff Tweedy was the founder and leader of the enormously popular band Wilco, he was a kid in Illinois with severe migraines and a tendency toward anxiety and depression. He cycled through alcohol, marijuana, and, finally, opioids to try to get to the point of feeling normal and okay, even relying on a […]

With one recent appearance on The Tonight Show, Patti Harrison went from being a well-regarded alternative comedian in New York to being a de facto spokesperson for transgender people. She’s proud of who she is and proud to give a voice to that community. But she wants to make it clear that her sense of […]

Although Gary Gulman has been a successful stand-up comedian for decades – with acclaimed specials, a loyal fan base, and appearances on all major late night shows – this was not his original plan. Gary is 6’6” and athletically gifted, he loved basketball, and had a full ride athletic scholarship to a Division 1 program. […]

Singer/songwriter Aimee Mann has a reputation for making music that is raw, emotional, and sometimes not all that cheerful. In real life, she’s perfectly cheerful – thank you very much – and has traveled a long road of depression, anxiety, a difficult childhood, and writer’s block. Through it all, she’s taken a calm, considered, and […]

Author John Green had one of the best-selling books of the last 10 years with The Fault In Our Stars. The problem is, when you write an acclaimed smash hit, everyone wants you to somehow do it again. In attempting to write that follow-up, Green went off the meds he’d been taking for Obsessive-Compulsive Disorder, […]

If you’ve enjoyed any comedy in the last 20 years, there’s a good chance Neal Brennan helped make it. He’s a veteran comic, writer, director, and co-creator, with Dave Chappelle, of the acclaimed Chappelle’s Show. Over the past 20-plus years, he’s also tried everything he could think of to tame his depression. Hear Neal’s epic […]

She’s one of the most influential and innovative comedians of the last few decades, but before all that, Margaret Cho was a Korean-American girl growing up in the 1970s in San Francisco. We hear about the sometimes very darkly humorous ways her family and culture dealt with depression and suicide, and how she harnessed her […]

Wil Wheaton was a child star in Stand By Me, a regular on Star Trek: The Next Generation as a teenager, and has been trying to figure out his role in show business for a long time since then. He was dealing with the pressures of fame and the fickle tastes of Hollywood, all while […]

Season 2 of The Hilarious World of Depression starts on September 25, 2017. Get a jump on it by hearing from some of the comics, actors, authors, and musicians you’ll get to know this season.

What if clinical depression was not just a thing in someone’s brain but an actual other person entirely? What would they look like? Act like? Who would they be? And how would you interact with such a person? It’s a mental exercise that many find helpful in isolating the disease from the self to better […]

If you are having problems with your mental health, please get help. You’ve heard that before on this show and probably plenty of other places as well. But how do you actually do that? How do you go about finding professional help to get things on a better track? It’s a process that can be […]

Depression can be really hard to define, making it difficult for anyone who doesn’t have it to be understand it. And that can make the people who do have it feel that much more alone. We asked our listeners what movie, TV show, artwork, or other piece of culture gets depression right. The answers range […]